2017/2018 Tissue Chips for Disease Modeling and Efficacy Testing Projects
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Researchers view engineered 3-D vascularized neural tissues from a brain tissue chip. (Morgridge Institute for Research Photo)
In September 2017, NIH funded 13 institutions with initial two-year awards to further develop tissue chip models of human disease that mimic the pathology in major human organs and tissues. In February 2018, NCATS issued an additional award. The goals are to (1) support studies to develop in vitro disease models using primary tissue or induced pluripotent stem cell (iPSC)-derived patient cell sources on tissue/organ-on-chip platforms, (2) determine disease relevance of these models by preliminary testing of key experimental features, and (3) test the effectiveness of candidate drugs. See the 2017/2018 awarded projects.
Brigham and Women's Hospital
Kidney Microphysiological Analysis Platforms to Optimize Function and Model Disease*
Principal Investigators: Joseph Vincent Bonventre, M.D., Ph.D. (Brigham and Women’s Hospital) and Luke P. Lee, Ph.D. (University of California, Berkeley)
Grant Number: 1-UG3-TR-002155-01
*Funded by NCATS with additional funding from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
Cedars-Sinai Medical Center
Development of a Microphysiological Organ-on-Chip System to Model Amyotrophic Lateral Sclerosis and Parkinson’s Disease*
Principal Investigator: Clive Niels Svendsen, Ph.D.
Grant Number: 1-UG3-NS-105703-01
*Funded by the National Institute of Neurological Disorders and Stroke (NINDS) with additional funding from NCATS.
Columbia University Health Sciences
Integrated Microphysiological System of Cerebral Organoid and Blood Vessel for Disease Modeling and Neuropsychiatric Drug Screening
Principal Investigator: Kam W. Leong, Ph.D.
Grant Number: 1-UG3-TR-002151-01
*Funded by NCATS.
Columbia University in the City of New York, Morningside Heights
Multi-Tissue Platform for Modeling Systemic Pathologies*
Principal Investigator: Gordana Vunjak-Novakovic, M.S., Ph.D.
Grant Number: 1-UG3-EB-025765-01
*Funded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) with additional funding from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute of Environmental Health Sciences (NIEHS), National Institute of Dental and Craniofacial Research (NIDCR), and NCATS.
Duke University
Systemic Inflammation in Microphysiological Models of Muscle and Vascular Disease*
Principal Investigator: George A. Truskey, Ph.D.
Grant Number: 1-UG3-TR-002142-01
*Funded by NCATS with additional funding from NIAMS.
Harvard University
Lung-on-a-Chip Disease Models for Efficacy Testing*
Principal Investigator: Donald E. Ingber, M.A., M.D., Ph.D.
Grant Number: 1-UG3-HL-141797-01
*Funded by the National Heart, Lung, and Blood Institute (NHLBI) with additional funding from NCATS and NIEHS.
Harvard University
Multi-Scale Modeling of Inherited Pediatric Cardiomyopathies*
Principal Investigators: Kevin Kit Parker, M.S., Ph.D., and William Tswenching Pu, M.S., M.D.
Grant Number: 1-UG3-HL-141798-01
*Funded by NHLBI with additional funding from NCATS.
Northwestern University
Polycystic Ovary Syndrome (PCOS) and Androgen-Related Disease Modeling and Drug Testing in Multi-Organ Integrated Microfluidic Reproductive Platform*
Principal Investigator: Teresa K. Woodruff, Ph.D.
Grant Number: 1-UG3-ES-029073-01
*Funded by NIEHS with additional funding from the NIH Office of the Director and NCATS.
University of California, Davis
A 3-D In Vitro Disease Model of Atrial Conduction*
Principal Investigators: David Terry Curiel, M.D., Ph.D. (Washington University in St. Louis); Steven Carl George, M.D., Ph.D. (University of California, Davis); and Stacey Lynn Rentschler, M.D., Ph.D. (Washington University in St. Louis)
Grant Number: 1-UG3-HL-141800-01
*Funded by NHLBI with additional funding from NCATS.
University of California, Irvine
Microphysiological Systems to Model Vascular Malformations*
Principal Investigator: Christopher C.W. Hughes, Ph.D.
Grant Number: 1-UG3-HL-141799-01
*Funded by NHLBI with additional funding from NCATS.
University of Pittsburgh
Tissue Chip Modeling of Synovial Joint Pathologies: Effects of Inflammation and Adipose-Mediated Diabetic Complications*
Principal Investigator: Rocky S. Tuan, Ph.D.
Grant Number: 1-UG3-TR-002136-01
*Funded by NCATS with additional funding from NIAMS.
University of Rochester
Engineered Salivary Gland Tissue Chips*
Principal Investigators: Danielle S. Benoit, M.S., Ph.D., Lisa A. Delouise, Ph.D., and Catherine Ovitt, Ph.D.
Grant Number: 1-UG3-DE-027695-01
*Funded by NIDCR with additional funding from NCATS.
University of Washington
A Microphysiological System for Kidney Disease Modeling and Drug Efficacy Testing*
Principal Investigator: Jonathan Himmelfarb, M.D.
Grant Number: 1-UG3-TR-002158-01
*Funded by NCATS with additional funding from NIDDK.
Vanderbilt University
Drug Development for Tuberous Sclerosis Complex and Other Pediatric Epileptogenic Diseases Using Neurovascular and Cardiac Microphysiological Models*
Principal Investigators: Aaron B. Bowman, Ph.D., Kevin C. Ess, M.D., Ph.D., and John Peter Wikswo, M.S., Ph.D.
Grant Number: 1-UG3-TR-002097-01
*Funded by NCATS with additional funding from NINDS.