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Challenges and Prize Competitions

Our program engages a diverse group of people from all over the country to collaborate and stimulate innovative ideas.

Challenges and Prize Competitions

We organize Challenges and Prize Competitions to discover creative solutions to critical issues. See our open Challenges below.

Learn more about Challenges across the federal government.


Open Challenges

NIH Quantum Computing Challenge

NIH Quantum Computing Challenge aims to catalyze the identification of novel applications of quantum computing approaches to apply toward use cases within clinical, translational, and biomedical problem areas. The Challenge will have two stages: Ideation and Planning followed by Quantum Algorithm Development, and Implementation on Quantum Hardware. NIH-NCATS intends to award a total prize purse of up to $1,300,000 across the two stages of Quantum Computing Challenge. The three areas of interest for the current Challenge include:

  1. Quantum Algorithms for Drug Discovery
  2. Quantum Algorithms for Clinical Risk Predictions, Diagnosis, and Therapeutics
  3. Quantum Algorithms for Biomedical Imaging and Genomic Data Analysis

Registration information and complete submissions (PDF files) must be sent via email to NIH Quantum Challenges.

NCATS Translational Science Education & Training Challenge

The NCATS Translational Science Education and Training Challenge seeks exemplary models of translational science education and training. The models should contribute to building a large, diverse and highly skilled translational science workforce. Winning models will convey specialized knowledge and skills to help identify and overcome translational challenges and advance translational progress. They will use effective teaching approaches tailored to reach the varied contributors that are essential to advancing the translational enterprise. The Challenge will identify, amplify and disseminate winning models to a broad national audience.

NIH Quantum Sensing Technology Challenge

The NIH Quantum Sensing Technology Challenge aims to spur innovative applications of existing quantum-enabled sensing technologies and to adapt and optimize them for use in biomedical research and clinical settings. The Challenge will have two stages: Ideation and Planning followed by implementation. The total prize purse for the Quantum Sensing Challenge will be up to $1,600,000 across two stages. The three areas of interest for the current challenge are the following:

  1. Quantum-enabled Sensing Approaches to Advance Biomedical Applications
  2. Quantum-enabled Sensing Approaches for Early Detection and Diagnostics
  3. Quantum-enabled Sensing and Imaging Devices for Diagnostics and Monitoring

Registration information and complete submissions (PDF files) must be sent via email to NIH Quantum Challenges.

Complement-ARIE Challenge

The Complement-Animal Research In Experimentation (Complement-ARIE) program is looking for ideas to boost the creation, standardization, validation, and application of New Approach Methodologies that better imitate human biology. Solutions should include cutting-edge innovations using cell or tissue experiments (in vitro), computer simulations and modeling (in silico), or biochemical assays (in chemico) to replicate human biology, either individually or in combination. It’s important that solutions show a significant step forward from the current advanced technologies.

TARGETED Challenge

The TARGETED (Targeted Genome Editor Delivery) Challenge aims to advance genome editing delivery technology by sourcing innovative solutions for delivering gene editors to somatic cells.


Challenge and Prize Competition Winners

Last updated on September 30, 2024