Description

NCATS, a major research component of NIH, seeks applications from exceptional candidates to fill a postdoctoral fellowship position within the Assay Development and Screening Technology (ADST) laboratory of James Inglese, Ph.D., within the center’s Division of Preclinical Innovation (DPI). The DPI is home to approximately 230 biologists, medicinal chemists and computational scientists who work on a broad portfolio of preclinical drug discovery projects and with programs that involve developing innovative new technologies to enable the acceleration of biomedical research.

The ADST laboratory is interested in discovering and developing novel molecular modalities for a variety of therapeutic indications — including cancer — with particular emphasis on rare metabolic disease applications. The current focus is on the evaluation of antifolate-based proteolysis targeting chimera chemical libraries to define target profiles and underlying mechanisms of action. This research will involve the design and implementation of CRSIPR/Cas9 genome edited reporter cell lines to interrogate the molecular pharmacology and biochemical network of one-carbon metabolism using these chemical libraires. Compounds of interest will be characterized using proteomics and metabolomics analysis and, depending on their properties, assessed in synthetic lethality functional genomics and conditional combination drug screens. Candidate molecules displaying novel pharmacology will enter a collaborative therapeutic development program involving medicinal chemistry optimization accompanied by relevant in vivo cancer or relevant models associated with rare disorders.

Recent research from this laboratory relevant to the position can be found at https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(23)00333-1.

For more information about the laboratory, see https://www.youtube.com/watch?v=VxtpySnbX-c and https://ncats.nih.gov/about/divisions-and-staff/jinglese.